LI Xiao-Qin1,2, LUO Liao-Fu1,2*, LIU Ci-Quan1*
( 1 Kunming Institute of Zoology, the Chinese
Academy of Science, Kunming 650223, China;
2 Department of Physics, Inner Mongolia University, Hohhot 010021,
China )
Abstract Based on the statistical analysis of 119
human and 92 E. coli proteins it was found that for both human and E.
coli, the mRNA sequences consisting of tri-codon and tetra-codon with high
translation speed preferably code for alpha helices more than for coils. For
beta strand, the preference/avoidance oscillates with the translation speed.
Moreover, the non-homogeneous usages of tri-codon and tetra-codon with
different translation speeds in a given secondary structure have also been
found. These results cannot be simply explained by the effect of stochastic
fluctuation.
Key words
mRNA sequence; protein secondary structure; translation speed
Corresponding
author:
LUO Liao-Fu: Tel,
86-28-85422749; Fax, 86-28-85501518; e-mail, [email protected]
LIU Ci-Quan: Tel, 86-871-5195183; Fax, 86-871-5191823; e-mail, [email protected]